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Polymorph screening Cocrystal screening Crystallization development IP support

▶ Impurity quantification

发布时间： 2015 - 09 - 23

Quantification of extremely low levels of impurity can be difficult. The detection limit and sensitivity provided by each technique also vary with solid properties. We have developed a comprehensive experience of effectively combining different technologies with proper data processing methods, which allows an accurate quantification even for samples with very low levels of impurity.

▶ Trouble shooting

发布时间： 2015 - 09 - 23

It is critical to utilize existing data and plan an efficient pathway to identify the root-cause of pharmaceutical failures. No matter if they are early preclinical issues regarding pure substances, excipients, or complex processing and formulation problems, we can offer immediate assistance, deliver relevant and useful suggestions in close collaborations with our customer. Just name a few examples where the key to solving challenging problems actually resides in the solid state aspects, for in...

▶ Amorphous materials

发布时间： 2015 - 09 - 23

Preparation of amorphous Depending on the chemical nature of each model compound, we offer service and suggestions on selecting suitable methods for ‘destroying’ crystalline into amorphous with high stability and chemical/physical purity. Commonly utilized techniques including: (1) From liquid phase to amorphous solid – freezing-in disorder ◆ Spraying drying ◆ Quench cooling ◆ Melt extrusion ◆ Super critical fluids ◆ Co-precipitation (2) From crystalline solid to amorphous solid – inducing disor...

▶ Excipient compatibility screening

发布时间： 2015 - 09 - 23

Excipients are indispensible for a tablet formulation. There are numerous excipients with different chemical functionalities and diverse physiochemical properties that may be selected for a given compound. It is important to carefully evaluate the potential of different excipients, and rationally choose compound combinations that represent a safe way forward in terms of chemical compatibility and/or physical stability. Based on our extensive experience, main areas listed as follows can be evalua...

▶ Solid dispersion screening

发布时间： 2015 - 09 - 23

We provide service for an effective solid dispersion screen focusing on the aspects as below: ◆ Rational excipient screen ◆ Formulation design and optimization ◆ Solubility testing while monitoring solid state of API ◆ Stability tests and behavior prediction

▶ Raman and polymorphic analysis

发布时间： 2015 - 09 - 25

Raman spectroscopy has only recently arisen as one of the commonly used molecular motion probing techniques. The invention of Raman spectroscopy goes back to 1928 when the Indian physicist C.V. Raman first found that the wavelength of a small fraction of the radiation scattered by certain molecules differs from that of the incident beam. This discovery led Raman to be awarded the Nobel Prize in Physics in 1931. Chandrasekhara Venkata RAMAN, 1928 The energy levels explored by Raman spectroscopy a...

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