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发布时间: 2015 - 09 - 25
Raman spectroscopy has only recently arisen as one of the commonly used molecular motion probing techniques. The invention of Raman spectroscopy goes back to 1928 when the Indian physicist C.V. Raman first found that the wavelength of a small fraction of the radiation scattered by certain molecules differs from that of the incident beam. This discovery led Raman to be awarded the Nobel Prize in Physics in 1931. Chandrasekhara Venkata RAMAN, 1928 The energy levels explored by Raman spectroscopy a...
发布时间: 2015 - 09 - 25
a. Effect of water on Raman spectra One of the major advantages of Raman is that water has very weak Raman scattering. Therefore, Raman can be utilized in various aqueous formulations without the influence of the presence of water. The suspensions were measured directly by Raman without the need of any sample preparation. Because of the weak Raman scattering of water, the chemical composition as well as the polymorphic form of API can be easily identified by Raman. Further reading:Sandler N et a...
发布时间: 2015 - 09 - 25
Raman could help generate valuable process data to ensure optimal process control, comprehensive process understanding at a molecular level and maximum efficiency in pharmaceutical production. Various factors can possibly induce solid state changes during pharmaceutical processing, as illustrated below. To ensure a robust processing, a key aspect of FDA's process analytical technology (PAT) philosophy is that every stage of the manufacturing process should be monitored and understood so that...
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