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Products Solid State Understanding
发布时间: 2015 - 09 - 23
Polymorphism can influence every aspect of the properties of a solid including the shelf life, dissolution rate, solubility, formulation properties and processing properties of a solid drug. A deeper understanding of polymorphism and related solid state properties would ensure an improved quality of the materials used throughout drug preparation, dosage form formulation and clinical trials. Therefore, determination of the existence of polymorphs and pseudopolymorphs, characterization of differen...
发布时间: 2015 - 09 - 23
When discovering the ‘true’ identity of each solid form, single crystal X-ray crystallography has been accepted as one of the definitive approaches. Utilizing our crystallization knowledge and experiences, we offer direct guidance and service on crystallization of perfectly grown and pure single crystals. Morphology of a typical CBZ single crystal and Miller indices of three faces (A), and position of the crystals mounted on the sample holder (B). Further reading: Tian F, Sandler N, Gordon KC, ...
发布时间: 2015 - 09 - 23
Quantification of extremely low levels of impurity can be difficult. The detection limit and sensitivity provided by each technique also vary with solid properties. We have developed a comprehensive experience of effectively combining different technologies with proper data processing methods, which allows an accurate quantification even for samples with very low levels of impurity.
发布时间: 2015 - 09 - 23
It is critical to utilize existing data and plan an efficient pathway to identify the root-cause of pharmaceutical failures. No matter if they are early preclinical issues regarding pure substances, excipients, or complex processing and formulation problems, we can offer immediate assistance, deliver relevant and useful suggestions in close collaborations with our customer. Just name a few examples where the key to solving challenging problems actually resides in the solid state aspects, for in...
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